Immunohistochemistry Kits and Reagents
ABclonal Technology Phospho-p38 MAPK-T180 Rabbit pAb
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Medchemexpress LLC P38-α MAPK-IN-1 | 443913-15-3 | 99.7% | 477.60 | 5 MG
p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α) that demonstrates inhibitory activity in both EFC displacement and HTRF assays. It also effectively inhibits LPS-induced tumor necrosis factor-alpha (TNF-alpha) production in THP-1 cells. This product is intended for research use only.
- Inhibits MAPK14 (p38-α)
- Effective in EFC displacement and HTRF assays
- Inhibits LPS-induced tumor necrosis factor-alpha (TNF-alpha) production
ABclonal Technology Phospho-p38 MAPK-T180/Y182
This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes including cell proliferation differentiation transcriptional regulation and development The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs) Alternative splicing results in multiple transcript variants [provided by RefSeq Mar 2014]
ABclonal Technology Phospho-β-Catenin-S675 Rabbit pAb
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
ABclonal Technology HBG1 Rabbit pAb
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is 5-epsilon -- gamma-G -- gamma-A -- delta -- beta--3.
Meso Scale Discovery R-PLEX Human Calbindin ASYQP
The R-Plex Human Calbindin Assay from Meso Scale Diagnostics is a multiplex immunoassay measuring calbindin in human serum plasma urine and other matrices It uses electrochemiluminescence (ECL) detection for high sensitivity a wide dynamic range and low sample volume This assay quantifies calbindin a calcium-binding protein in the intestine and kidneys aiding in diagnosing diseases related to calbindin levels The kit includes a 96-well plate with capture antibodies detection antibodies calibrators and necessary reagents
Biotium Cytokeratin 8/18(B22.1 + B23.1), CF740 conjugate, 0.1mg/mL
Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). This MAb cocktail recognizes all simple epithelia including glandular epithelium, for example thyroid, female breast, gastrointestinal tract, respiratory tract, and urogenital tract including transitional epithelium. All adenocarcinomas and most squamous carcinomas are positive but keratinizing squamous carcinomas are usually negative. This antibody is useful in demonstrating the presence of Paget cells; there is very little keratin 18 in the normal epidermis so only Paget cells are stained.Immunohistochemical staining with this MAb is indistinguishable from that obtained with monoclonal antibody 5D3.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S an
Biotium Uroplakin 1A (Urothelial Differentiation Marker)(UPK1A/2923), CF740 conjugate, 0.1mg/mL
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like
Bioss p38 MAP Kinase - C-terminal M
p38 MAP Kinase (C-terminal) M138 Primary Antibody Unconjugated Host Species Mouse Target Species Human Mouse Rat Clonality Monoclonal Applications WB M138Concentration Size 100 ul Storage Buffer PBS 1 mg/ml BSA 0 05% NaN3 and 50% glycerol
Biotium Uroplakin 1A (Urothelial Differentiation Marker)(UPK1A/2923), Biotin conjugate, 0.1mg/mL
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like
ABclonal Technology S100P Rabbit pAb
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21, however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer.
Biolegend Biotinylated Recombinant Human Nectin3-Fc Chimera (carrier-free); Reactivity: Human; Apps: BA; Size: 25 μg
Biotinylated Recombinant Human Nectin3-Fc Chimera (carrier-free); Reactivity: Human; Apps: BA; Size: 25 μg
Meso Scale Discovery RPLEX HUM FABP3/HFABP ASYQP
The R-PLEX Human FABP3 (H-FABP) Assay Kit from Meso Scale Diagnostics is used to quantitatively measure human heart-type fatty acid binding protein (H-FABP) in serum plasma cell culture supernatants cell and tissue lysates using an electrochemiluminescent detection technology The assay has high sensitivity and wide dynamic range This multiplex kit includes a 96-well plate coated with capture antibody detection antibody read buffer wash buffer sample diluent calibrator diluent and lyophilized calibrator The assay takes 3 5 hours to complete
Biotium Cytokeratin 8(C-43), CF740 conjugate, 0.1mg/mL
Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant)